This paper describes an analysis of the effects of electric field on nerve cells by using the Hodgkin-Huxley model. When evaluating our model, which combines an additional ionic current source and generated membrane potential, we derive the peak-to-peak value, the accumulated square of variation, and Kolmogorov-Sinai (KS) entropy of the cell-membrane potential excited by 10, 100, 1 k, and 10 kHz-sinusoidal electric fields. In addition, to obtain a comprehensive view of the time-variation patterns of our model, we used a self-organizing map, which provides a way to map high-dimensional data onto a low-dimensional domain. Simulation results confirmed that lower-frequency electric fields tended to increase fluctuations of the cell-membrane potential, and the additional ionic current source was a more dominant factor for fluctuations of the cell-membrane potential. On the basis of our model, we visually confirmed that the obtained data could be projected onto the map in accordance with responses of cell-membrane potential excited by electric fields, resulting in a combined depiction of the effects of KS entropy and other parameters.
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Masao MASUGI, Kazuo MURAKAWA, "Hodgkin-Huxley Model-Based Analysis of Electric-Field Effect on Nerve Cell Using Self-Organizing Map" in IEICE TRANSACTIONS on Communications,
vol. E92-B, no. 6, pp. 2182-2192, June 2009, doi: 10.1587/transcom.E92.B.2182.
Abstract: This paper describes an analysis of the effects of electric field on nerve cells by using the Hodgkin-Huxley model. When evaluating our model, which combines an additional ionic current source and generated membrane potential, we derive the peak-to-peak value, the accumulated square of variation, and Kolmogorov-Sinai (KS) entropy of the cell-membrane potential excited by 10, 100, 1 k, and 10 kHz-sinusoidal electric fields. In addition, to obtain a comprehensive view of the time-variation patterns of our model, we used a self-organizing map, which provides a way to map high-dimensional data onto a low-dimensional domain. Simulation results confirmed that lower-frequency electric fields tended to increase fluctuations of the cell-membrane potential, and the additional ionic current source was a more dominant factor for fluctuations of the cell-membrane potential. On the basis of our model, we visually confirmed that the obtained data could be projected onto the map in accordance with responses of cell-membrane potential excited by electric fields, resulting in a combined depiction of the effects of KS entropy and other parameters.
URL: https://global.ieice.org/en_transactions/communications/10.1587/transcom.E92.B.2182/_p
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@ARTICLE{e92-b_6_2182,
author={Masao MASUGI, Kazuo MURAKAWA, },
journal={IEICE TRANSACTIONS on Communications},
title={Hodgkin-Huxley Model-Based Analysis of Electric-Field Effect on Nerve Cell Using Self-Organizing Map},
year={2009},
volume={E92-B},
number={6},
pages={2182-2192},
abstract={This paper describes an analysis of the effects of electric field on nerve cells by using the Hodgkin-Huxley model. When evaluating our model, which combines an additional ionic current source and generated membrane potential, we derive the peak-to-peak value, the accumulated square of variation, and Kolmogorov-Sinai (KS) entropy of the cell-membrane potential excited by 10, 100, 1 k, and 10 kHz-sinusoidal electric fields. In addition, to obtain a comprehensive view of the time-variation patterns of our model, we used a self-organizing map, which provides a way to map high-dimensional data onto a low-dimensional domain. Simulation results confirmed that lower-frequency electric fields tended to increase fluctuations of the cell-membrane potential, and the additional ionic current source was a more dominant factor for fluctuations of the cell-membrane potential. On the basis of our model, we visually confirmed that the obtained data could be projected onto the map in accordance with responses of cell-membrane potential excited by electric fields, resulting in a combined depiction of the effects of KS entropy and other parameters.},
keywords={},
doi={10.1587/transcom.E92.B.2182},
ISSN={1745-1345},
month={June},}
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TY - JOUR
TI - Hodgkin-Huxley Model-Based Analysis of Electric-Field Effect on Nerve Cell Using Self-Organizing Map
T2 - IEICE TRANSACTIONS on Communications
SP - 2182
EP - 2192
AU - Masao MASUGI
AU - Kazuo MURAKAWA
PY - 2009
DO - 10.1587/transcom.E92.B.2182
JO - IEICE TRANSACTIONS on Communications
SN - 1745-1345
VL - E92-B
IS - 6
JA - IEICE TRANSACTIONS on Communications
Y1 - June 2009
AB - This paper describes an analysis of the effects of electric field on nerve cells by using the Hodgkin-Huxley model. When evaluating our model, which combines an additional ionic current source and generated membrane potential, we derive the peak-to-peak value, the accumulated square of variation, and Kolmogorov-Sinai (KS) entropy of the cell-membrane potential excited by 10, 100, 1 k, and 10 kHz-sinusoidal electric fields. In addition, to obtain a comprehensive view of the time-variation patterns of our model, we used a self-organizing map, which provides a way to map high-dimensional data onto a low-dimensional domain. Simulation results confirmed that lower-frequency electric fields tended to increase fluctuations of the cell-membrane potential, and the additional ionic current source was a more dominant factor for fluctuations of the cell-membrane potential. On the basis of our model, we visually confirmed that the obtained data could be projected onto the map in accordance with responses of cell-membrane potential excited by electric fields, resulting in a combined depiction of the effects of KS entropy and other parameters.
ER -