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A Local Multi-Layer Model for Tissue Classification of in-vivo Atherosclerotic Plaques in Intravascular Optical Coherence Tomography

Xinbo REN, Haiyuan WU, Qian CHEN, Toshiyuki IMAI, Takashi KUBO, Takashi AKASAKA

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Summary :

Clinical researches show that the morbidity of coronary artery disease (CAD) is gradually increasing in many countries every year, and it causes hundreds of thousands of people all over the world dying for each year. As the optical coherence tomography with high resolution and better contrast applied to the lesion tissue investigation of human vessel, many more micro-structures of the vessel could be easily and clearly visible to doctors, which help to improve the CAD treatment effect. Manual qualitative analysis and classification of vessel lesion tissue are time-consuming to doctors because a single-time intravascular optical coherence (IVOCT) data set of a patient usually contains hundreds of in-vivo vessel images. To overcome this problem, we focus on the investigation of the superficial layer of the lesion region and propose a model based on local multi-layer region for vessel lesion components (lipid, fibrous and calcified plaque) features characterization and extraction. At the pre-processing stage, we applied two novel automatic methods to remove the catheter and guide-wire respectively. Based on the detected lumen boundary, the multi-layer model in the proximity lumen boundary region (PLBR) was built. In the multi-layer model, features extracted from the A-line sub-region (ALSR) of each layer was employed to characterize the type of the tissue existing in the ALSR. We used 7 human datasets containing total 490 OCT images to assess our tissue classification method. Validation was obtained by comparing the manual assessment with the automatic results derived by our method. The proposed automatic tissue classification method achieved an average accuracy of 89.53%, 93.81% and 91.78% for fibrous, calcified and lipid plaque respectively.

Publication
IEICE TRANSACTIONS on Information Vol.E102-D No.11 pp.2238-2248
Publication Date
2019/11/01
Publicized
2019/08/15
Online ISSN
1745-1361
DOI
10.1587/transinf.2018EDP7404
Type of Manuscript
PAPER
Category
Biological Engineering

Authors

Xinbo REN
  Wakayama University,Shangluo University
Haiyuan WU
  Wakayama University
Qian CHEN
  SenseTime Japan Ltd.
Toshiyuki IMAI
  Wakayama University
Takashi KUBO
  Wakayama Medical University
Takashi AKASAKA
  Wakayama Medical University

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