We report recent progress in the development of Liquid Crystal(LC) materials for the TN-TFT and ECB-TFT technologies, which require LC materials with positive and negative dielectric anisotropy, respectively. Many kinds of new LC materials have been synthesized and have been evaluated based on their fundamental physical properties. We have succeeded in identifying new LC materials, and developing new LC mixtures based on those, so that the current typical requirements of TFT-LCDs e.g. fast switching times, low power consumption, good viewing angles and wide operation temperature ranges together with high reliability can be fulfilled.