Unsupervised Feature selection is an important dimensionality reduction technique to cope with high-dimensional data. It does not require prior label information, and has recently attracted much attention. However, it cannot fully utilize the discriminative information of samples, which may affect the feature selection performance. To tackle this problem, in this letter, we propose a novel discriminative virtual label regression method (DVLR) for unsupervised feature selection. In DVLR, we develop a virtual label regression function to guide the subspace learning based feature selection, which can select more discriminative features. Moreover, a linear discriminant analysis (LDA) term is used to make the model be more discriminative. To further make the model be more robust and select more representative features, we impose the ℓ2,1-norm on the regression and feature selection terms. Finally, extensive experiments are carried out on several public datasets, and the results demonstrate that our proposed DVLR achieves better performance than several state-of-the-art unsupervised feature selection methods.