This study is focused on the automated detection of a complex system operator's condition. For example, in this study a person's reaction while listening to music (or not listening at all) was determined. For this purpose various well-known data mining tools as well as ones developed by authors were used. To be more specific, the following techniques were developed and applied for the mentioned problems: artificial neural networks and fuzzy rule-based classifiers. The neural networks were generated by two modifications of the Differential Evolution algorithm based on the NSGA and MOEA/D schemes, proposed for solving multi-objective optimization problems. Fuzzy logic systems were generated by the population-based algorithm called Co-Operation of Biology Related Algorithms or COBRA. However, firstly each person's state was monitored. Thus, databases for problems described in this study were obtained by using non-contact Doppler sensors. Experimental results demonstrated that automatically generated neural networks and fuzzy rule-based classifiers can properly determine the human condition and reaction. Besides, proposed approaches outperformed alternative data mining tools. However, it was established that fuzzy rule-based classifiers are more accurate and interpretable than neural networks. Thus, they can be used for solving more complex problems related to the automated detection of an operator's condition.