The volume of mass unsolicited electronic mail, often known as spam, has recently increased enormously and has become a serious threat not only to the Internet but also to society. This paper proposes a new spam detection method which uses document space density information. Although the proposed method requires extensive e-mail traffic to acquire the necessary information, it can achieve perfect detection (i.e., both recall and precision is 100%) under practical conditions. A direct-mapped cache method contributes to the handling of over 13,000 e-mail messages per second. Experimental results, which were conducted using over 50 million actual e-mail messages, are also reported in this paper.