For time-delay systems with mismatched disturbances and uncertainties, this paper developed an integral sliding mode control algorithm using output information only to stabilize the system. An integral sliding surface is comprised of output vectors and an auxiliary full-order compensator. The proposed output feedback sliding mode controller can satisfy the reaching and sliding condition and maintain the system on the sliding surface from the initial moment. When the specific linear matrix inequality has a solution, our method can guarantee the stability of the closed-loop system and satisfy the property of disturbance attenuation. Moreover, the design parameters of the controller and compensator can be simultaneously determined by the solution to the linear matrix inequality. Finally, a numerical example illustrated the applicability of the proposed scheme.