Space-time block codes (STBCs) from coordinate interleaved orthogonal designs (CIODs) have attracted a great deal of attention due to their full-diversity and linear maximum likelihood (ML) decodability. In this letter, we propose a simple detection technique, particularly for full-rate STBCs from CIODs to overcome the performance degradation caused by time-selective fading channels. Furthermore, we evaluate the effects of time-selective fading channels and imperfect channel estimation on STBCs from CIODs by using a newly-introduced index, the results of which demonstrate that full-rate STBCs from CIODs are more robust against time-selective fading channels than conventional full-rate STBCs.