In this paper, we propose a genetic algorithm (GA) based equalization approach for direct sequence ultra-wideband (DS-UWB) wireless communication systems, where the GA is combined with a RAKE receiver to combat the inter-symbol interference (ISI) due to the frequency selective nature of UWB channels for high data rate transmission. The proposed GA based equalizer outperforms significantly the RAKE and the RAKE-minimum mean square error (MMSE) receivers according to results obtained from intensive simulation work. The RAKE-GA receiver also provides bit-error-rate (BER) performance very close to that of the optimal RAKE-maximum likelihood detection (MLD) approach, while offering a much lower computational complexity.