We studied the possibility of making an objective diagnosis of dementia based on radiological findings by evaluating cerebral and hippocampal atrophy and the corpus callosum shape on MRI images in patients with Alzheimer-type dementia, compared with healthy elderly individuals. There was a statistically significant difference in the hippocampus area index, the ventricle area index, and the area ratio for the second, forth, and fifth parts of corpus callosum. Discriminant analysis using these three parameters demonstrated the sensitivity of 88.5% and the specificity of 85.7%, suggesting a highly positive diagnostic rate. These results indicate that quantitative MRI measurements could be used for differentiating Alzheimer-type dementia from similar diseases.

In screening for primary lung cancer with plain chest radiography, computer-aided diagnosis systems are being developed to reduce chest radiologists' task and the risk of missing positive cases. We evaluated a difference filter that enhances nodule densities in the preprocessing of chest X-ray images. Since ribs often affect detection of pulmonary nodules, we designed an eye-shaped filter to fit the rib shape. Although this filter increased the nodule detection rate, it could not detect nodules near the thoracic wall. The thoracic wall was then outlined by computers with Hough transformation for line detection. On the basis of the outline, the direction of the eye-shaped filter was determined. With this technique, the filter was not affected by considerable changes in the shape of anatomical structures, such as ribs and the thoracic wall, and could detect pulmonary nodules regardless of their location.