The spectral efficiency of photonic networks can be enhanced by the use of higher modulation orders and narrower channel bandwidth. Unfortunately, these solutions are precluded by the margins required to offset uncertainties in system performance. Furthermore, as recently highlighted, the disaggregation of optical transport systems increases the required margin. We propose here highly spectrally efficient networks, whose margins are minimized by transmission-quality-aware adaptive modulation-order/channel-bandwidth assignment enabled by optical performance monitoring (OPM). Their effectiveness is confirmed by experiments on 400-Gbps dual-polarization quadrature phase shift keying (DP-QPSK) and 16-ary quadrature amplitude modulation (DP-16QAM) signals with the application of recently developed Q-factor-based OPM. Four-subcarrier 32-Gbaud DP-QPSK signals within 150/162.5/175GHz and two-subcarrier 32-Gbaud DP-16QAM signals within 75/87.5/100GHz are experimentally analyzed. Numerical network simulations in conjunction with the experimental results demonstrate that the proposed scheme can drastically improve network spectral efficiency.