A blind symbol synchronization scheme for MIMO and Multi-User OFDM systems is proposed, which utilizes short-time Fourier Transformation (STFT) to obtain 2D (time and frequency) timing information from the received signals. By analyzing the obtained 2D time-frequency amplitude spectrum, intervals where no inter-symbol interference (ISI) exists are checked out for symbol synchronization, and samples during these intervals are used to carry out carrier frequency offset estimation. Theoretical analysis and simulation results show that the proposed method is more robust and provides more accurate carrier frequency offset estimation than traditional schemes.