With the rising innovative antigens (such as intruders and viruses) through Internet, reliable security mechanisms are required to perceptively detect and put them down. However, defense techniques of the current host system over Internet may not properly analyze Internet antigens, because trends of attacks are unexpectedly shifted. In this paper, we introduce an Antibody Layer that mediates proper security services based on the biological mechanism to rapidly disclose and remove innovative antigens. The proposed Antibody Layer also employs a new topology called antibody cooperation protocol to support real-time security QoS for one host as well as host alliance.