Hardware Trojan or any other kind of unwanted hardware modifications has been thought as a major challenge in many commercial and secure applications. Currently, detection and prevention of hardware Trojans appeared as an important requirement in such systems. In this paper, a new concept, Trojan Vulnerability Map, is introduced to model the immunity of various regions of hardware against hardware attacks. Then, placement and routing algorithms are proposed to improve the immunity of hardware using the Trojan Vulnerability Map. Experimental results show that the proposed placement and routing algorithm reduces the hardware vulnerability by 25.65% and 4.08%, respectively. These benefits are earned in cost of negligible total wire length and delay overhead.