We propose a theory of general frame multiresolution analysis (GFMRA) which generalizes both the theory of multiresolution analysis based on an affine orthonormal basis and the theory of frame multiresolution analysis based on an affine frame to a general frame. We also discuss the problem of perfectly representing a function by using a wavelet frame which is not limited to being of affine type. We call it a "generalized affine wavelet frame." We then characterize the GFMRA and provide the necessary and sufficient conditions for the existence of a generalized affine wavelet frame.