In this paper, we investigate a user and antenna joint selection problem in multi-user large-scale MIMO downlink networks, where a BS with N transmit antennas serves K users, and N is much larger than K. The BS activates only S(S≤N) antennas for data transmission to reduce hardware cost and computation complexity, and selects the set of users to which data is to be transmitted by maximizing the sum-rate. The optimal user and antenna joint selection scheme based on exhaustive search causes considerable computation complexity. Thus, we propose a new joint selection algorithm with low complexity and analyze the performance of the proposed scheme in terms of sum-rate and complexity. When S=7, N=10, K=5, and SNR=10dB, the sum-rate of the proposed scheme is 5.1% lower than that of the optimal scheme, while the computation complexity of the proposed scheme is reduced by 99.0% compared to that of the optimal scheme.