In this study we present a new Laser Doppler Velocimeter (LDV) with an optical fiber to measure the velocity of blood flow accurately. After the validity of the present method was evaluated by the fundamental experiments, the blood flow profiles in canine femoral arteries were measured in anesthetized mongrel dogs. It was shown that our LDV is a valid and useful velocimeter to measure the phasic blood flow velocity in the artery.

This paper presents a new method to calculate the asymptotic variances as a measure of accuracy in the estimation of rate constants of a compartmental system. Several numerical tests have been performed to analyze the effects of sampling conditions on the asymptotic variances. It is shown that there exists the optimal sampling interval which minimizes the asymptotic variances.