In this letter, we derive an analytical expression for computing the symbol error probability (SEP) of the M-ary quadrature amplitude modulation (M-QAM) in the joint presence of phase/quadrature error and I/Q gain imbalance over an additive white Gaussian noise (AWGN) channel. The derived expression containing only the two-dimensional Gaussian Q-function can be used to compute the SEP of M-QAM in various fading channels by making use of the moment-generating function (MGF) approach.