A simple and novel multiple-symbol differential detection (MSDD) scheme is proposed for IEEE 802.15.4 binary phase shift keying (BPSK) receivers. The detection is initiated by estimating and compensating the carrier frequency offset (CFO) effect in the chip sample of interest. With these new statistics, the decisions are jointly made by allowing the observation window length to be longer than two bit intervals. Simulation results demonstrate that detection reliability of the IEEE 802.15.4 BPSK receivers is significantly improved. Namely, at packet error rate (PER) of 1×10-3, the signal-to-noise ratio (SNR) gap between ideal coherent detection (perfect carrier reference phase and no CFO) with differential decoding and conventional optimal single differential coherent detection (SDCD) is filled by 2.1dB when the observation window length is set to 6bit intervals. Then, the benefit that less energy consumed by retransmissions is successfully achieved.