To clarify the stereopsis disturbance in patients with Alzheimer's disease (AD), we analyzed binocular eye movement when subjects shifted their gaze between targets at different depths. Subjects are patients with Alzheimer's disease, Mluti-infarct dementia (MID), or Olivopontocerebellar atrophy (OPCA), and healthy controls. Targets are arranged in two ways: along the median plane and asymmetrically crossing the median plane, at distances from the eyes of 1000 mm and 300 mm. When the targets are switched at the onset of a beep, the subjects shifted their gaze to the lit target. The experiment is conducted in a dimly lit room whose structure is capable of providing good binocular cues for depth. In AD subjects, especially in the subjects whose symptoms are moderate (advanced stage), vergence is limited and the change in the convergence angle is small, unstable, and non-uniform. These results are different from those of other patients (MID) and OPCA) or healthy controls and suggest a disturbance of stereopsis in the parietal lobe where AD patients typically have dysfunctions.

With the advent of an aging society, the incidence of Alzheimer-type dementia (hereinafter referred to as AD for convenience) has drastically increased. Compared with classic cerebrovascular dementia, AD requires different therapeutic modalities. Despite such differences, it is difficult to establish a differential diagnosis of AD and cerebrovascular dementia. In the present paper, we analyze the neuropsychological symptoms and signs associated with AD, such as visual cognitive dysfunction, with particular attention to head and eye coordination. The subjects were allowed to gaze at targets disposed 1 m away and at a visual angle of 25 and 50 in order to compare healthy volunteers and patients with senile dementias such as multi-infarct dementia (MID). As a consequence, patients with AD presented clinical manifestations not seen in patients with other senile dementias; that is, (1) an increase in stepwise eye movement, (2) anisotropy in the velocity of right-directional and left-directional eye movements, (3) a decrease in the velocity of head movements (4) incomplete gaze, and (5) decreased head share.