This paper discusses the design of configurations of videophone equipment aimed at online sign interpretation. We classified interpretation services into three types of situations: on-site interpretation, partial online interpretation, and full online interpretation. For each situation, the spatial configurations of the equipment are considered keeping the issue of nonverbal signals in mind. Simulation experiments of sign interpretation were performed using these spatial configurations and the qualities of the configurations were assessed. The preferred configurations had the common characteristics that the hearing subject could see the face of his/her principal conversation partner, that is, the deaf subject. The results imply that hearing people who do not understand sign language utilize nonverbal signals for facilitating interpreter-mediated conversation.