In PMIPv6, all packets sent by mobile nodes or correspondent nodes are transferred through the local mobility anchor. This unnecessary detour results in high delivery latency and significant processing cost. Several PMIPv6 route optimization schemes have been proposed to solve this issue. However, they also suffer from the high signaling costs when determining the optimized path. The proposed scheme which adopts the prediction algorithm in PFMIPv6 can reduce the signaling costs of the previous schemes. Analytical performance evaluation is performed to show the effectiveness of the proposed scheme.