Silicon-on-insulator (SOI) has become one of the most famous materials in recent years, especially in silicon photonics applications. This paper presents a comparative performance of a SOI-based optical interconnect (OI) vs. an electrical interconnect (EI) for high-speed performances at a circuit level. The SOI-based optical waveguide was designed using OptiBPM to obtain a single mode condition (SMC). Then, the optical interconnect (OI) link was simulated in OptiSPICE and was tested as an interconnection in two-stage CS amplifiers. The results showed that the two-stage CS amplifier using OI offered several advantages in terms of electrical performances, such as voltage gain, frequency bandwidth, slew rate, and propagation delay, which makes it superior to the EI.