We investigate the potential of photonic crystal fiber (PCF) to realize high quality and high-power transmission. We utilize the PCF with a quasi-uniform air-hole structure, and numerically clarify that the quasi-uniform PCF can realize the effective area (Aeff) of about 500µm2 with bending loss comparable with that of a conventional single-mode fiber for telecom use by considering the quasi single-mode transmission. We then apply the quasi-uniform PCF to kW-class high-power beam delivery for the single-mode laser processing. The cross-sectional design of the PCF with the high-power delivery potential of more than 300kW·m is numerically and experimentally revealed. A 10kW single-mode beam at 1070nm is successfully delivered over a 30m-long optical fiber cable containing a fabricated PCF with single-mode class beam quality of M2 =1.7 for the first time.