Due to the lack of end-to-end paths between the communication source and destination in the Disruption Tolerant Network (DTN), its routing employs the store-carry-and-forward mechanism. In order to provide communication service in the DTN where there is only intermittent connectivity between nodes, a variety of epidemic-style routing algorithms have been proposed to achieve high message delivery probability at the cost of energy consumption. In this contribution, we investigate the problem of optimal multi-frame content transmission. By formulating the optimization problem with a Markov model, we derive the optimal policies under the two conditions of with and without energy constraint. We also investigate the performance of the proposed optimal policies through extensive numerical analyses, and conclude that the optimal policies give the best performance and the energy constraint critically degrades the system performance in the multi-frame content transmission.