This paper presents the performance of outer-loop control for selecting the best modulation and coding scheme (MCS) based on mutual information (MI) for orthogonal frequency division multiplexing (OFDM) multiple-input multiple-output (MIMO) spatial division multiplexing (SDM). We propose an outer-loop control scheme that updates the measured MI per information bit value for selecting the best MCS from a mapping table that associates the block error rate (BLER) and MI per bit instead of directly updating the MCS selection threshold so that the required BLER is satisfied. The proposed outer-loop control is applicable to continuous data transmission including intermittent transmission with a short blank period. Moreover, we compare the measured BLER and throughput performance for two types of outer-loop control methods: instantaneous block error detection and moving-average BLER detection. In the paper, we use maximum likelihood detection (MLD) for MIMO SDM. Computer simulation results optimize the step size for the respective outer-loop control schemes for selecting the best MCS that achieves the higher throughput and the target BLER simultaneously. Computer simulation results also show that by using the most appropriate step size, the outer-loop control method based on the instantaneous block error detection of each physical resource block is more appropriate than that based on the moving-average BLER detection from the viewpoints of achieving the target BLER more accurately and higher throughput.