Diffusion-weighted (DW)-functional magnetic resonance imaging (fMRI) is a recently reported technique for measuring neural activities by using diffusion-weighted imaging (DWI). DW-fMRI is based on the property that cortical cells swell when the brain is activated. This approach can be used to observe changes in water diffusion around cortical cells. The spatial and temporal resolutions of DW-fMRI are superior to those of blood-oxygenation-level-dependent (BOLD)-fMRI. To investigate how the DWI signal intensities change in DW-fMRI measurement, we carried out Monte Carlo simulations to evaluate the intensities before and after cell swelling. In the simulations, we modeled cortical cells as two compartments by considering differences between the intracellular and the extracellular regions. Simulation results suggested that DWI signal intensities increase after cell swelling because of an increase in the intracellular volume ratio. The simulation model with two compartments, which respectively represent the intracellular and the extracellular regions, shows that the differences in the DWI signal intensities depend on the ratio of the intracellular and the extracellular volumes. We also investigated the MPG parameters, b-value, and separation time dependences on the percent signal changes in DW-fMRI and obtained useful results for DW-fMRI measurements.

A technique is presented for the automated calculation and the imaging of the electric field around a moving animal. This technique is based on the numerical analysis of an electric field using the finite difference method. Its usefulness in practice is demonstrated by applying it to a free-moving mouse. The mouse is photographed in a 35 mm monochromatic film, and it is transformed in a digital image using a flying spot scanner (FSS). This image is used as a boundary condition for the numerical calculation of the electric field. The distributions of both equipotential lines and electric lines of force are plotted on an X-Y plotter. The intensity distribution of the electric field is presented in the luminance on a CRT display of the FSS and recorded on a film. The surface electric field of the animal body is calculated by extrapolation along the electric line of force and presented in vector patterns. It is shown quantatively that the electric field on the animal body (e.g. nose, back, ears) changes considerably as the animal changes its posture. This method is widely applicable to the objects with any shapes including a human.

We developed a novel movement-imagery-based brain-computer interface (BCI) for untrained subjects without employing machine learning techniques. The development of BCI consisted of several steps. First, spline Laplacian analysis was performed. Next, time-frequency analysis was applied to determine the optimal frequency range and latencies of the electroencephalograms (EEGs). Finally, trials were classified as right or left based on β-band event-related synchronization using the cumulative distribution function of pretrigger EEG noise. To test the performance of the BCI, EEGs during the execution and imagination of right/left wrist-bending movements were measured from 63 locations over the entire scalp using eight healthy subjects. The highest classification accuracies were 84.4% and 77.8% for real movements and their imageries, respectively. The accuracy is significantly higher than that of previously reported machine-learning-based BCIs in the movement imagery task (paired t-test, p < 0.05). It has also been demonstrated that the highest accuracy was achieved even though subjects had never participated in movement imageries.