This research addresses improvements in the efficiency of spectrum utilization by defending against jamming attacks and corrupting the communications of the adversary network by executing its own jamming strategy. The proposed scheme, based on game theory, selects the best operational strategy (i.e., communications and jamming strategies) to maximize the successful communications and jamming rates of the network. Moreover, an estimation algorithm is investigated to predict the behavior of the adversary network in order to improve the efficiency of the proposed game theory-based scheme.