Network structure has a great impact both on hazard spread and network immunization. The vulnerability of the network node is associated with each other, assortative or disassortative. Firstly, an algorithm for vulnerability relevance clustering is proposed to show that the vulnerability community phenomenon is obviously existent in complex networks. On this basis, next, a new indicator called network “hyper-betweenness” is given for evaluating the vulnerability of network node. Network hyper-betweenness can reflect the importance of network node in hazard spread better. Finally, the dynamic stochastic process of hazard spread is simulated based on Monte-Carlo sampling method and a two-player, non-cooperative, constant-sum game model is designed to obtain an equilibrated network immunization strategy.