Safety is the foremost requirement of avionics systems on aircraft. So far, avionics systems have evolved into an integrated system, i.e., integrated avionics system, and the derivative functions occur when the avionics systems are upgraded. However, the traditional safety analysis method is insufficient to be utilized in upgraded avionics systems due to these derivative functions. In this letter, a safety evaluation scheme is proposed to quantitatively evaluate the safety of the upgraded avionics systems. All the functions including the derivative functions can be traced and covered. Meanwhile, a set of safety issues based on different views is established to evaluate the safety capability from three layers, i.e., the mission layer, function layer and resource layer. The proposed scheme can be considered as an efficient scheme in the safety validation and verification in the upgraded avionics systems.