A new model for a computer simulation of RF capacitive type hyperthermia has been developed by taking account of the following points. Blood flow is usually determined by many physiological parameters, but is regarded as a function of only blood temperature under some conditions. The temperature dependence of blood flow of tumors and normal tissues is assumed by referring the data obtained by Song et al. and Tanaka. The blood temperature which is elevated by externally applied power significantly affects temperatures of the body and the tumors. The transport of heat from the body surface is studied by considering air convection. These points are examined by experiments on a computer with simple phantom models and real patients. The results of simulation on the patient have shown a good agreement with clinical inspection based on CT images and a temperature of the stomach.

Responses in the Nagumo neural circuit to pulse-train stimulation are studied using the time sequence, phase diagram, Poincare section, return map, firing rate, Lyapunov number and bifurcation diagram. For the mono-stable neuron with an equilibrium point deeper than the maximal point of a tunnel diode curve, main responses are periodic or all-or-none and chaotic responses are rarely observed. For the neuron with an equilibrium point located near the maximal point, the response to one input pulse oscillates after the undershoot and responses to pulse-trains make complex bifurcation structure in the threshold diagram. The ranges of periodic responses are stratified in the diagram. There exist broad regions of chaotic responses and chaos is not a special response of the Nagumo circuit, but it often comes out. The results are different from those obtained from Hodgkin-Huxley equations and the BVP model.