Medical imaging plays an indispensable role in precise patient diagnosis. The integration of deep learning into medical diagnostics is becoming increasingly common. However, existing deep learning models face performance and efficiency challenges, especially in resource-constrained scenarios. To overcome these challenges, we introduce a novel dendritic neural efficientnet model called DEN, inspired by the function of brain neurons, which efficiently extracts image features and enhances image classification performance. Assessments on a diabetic retinopathy fundus image dataset reveal DEN’s superior performance compared to EfficientNet and other classical neural network models.