In this paper the amplitude probability distribution (APD) measurement method is applied to evaluate noise coupling to an antenna on an evaluation board that uses mixed RF and digital signals of an IC. We analytically investigate noise coupling path to the antenna where the correlation coefficient matches the APD curve of the evaluation board. Moreover, in order to verify the analysis results, the noise coupling path in the board is evaluated by measurements involving In-phase/Quadrature (I/Q) signals as well as electromagnetic simulations. As a result, we demonstrate that APD method is effective in evaluating a degree of noise coupling from an IC to multiple antennas on the board, and confirm that the intensity of noise coupling to each antenna is affected greatly by the board layout patterns.