This paper presents a new general distance measure that not only can be used in a vector quantization (VQ) of line spectrum frequency (LSF) parameters but also performs well in a LSF transformed domain. The new distance is based on the spectral sensitivity of LSFs and their transformed coefficients. In addition, a fix scaling vector is used to decrease the sensitivity of spectral error at higher frequencies. Experimental results have shown that the proposed distance measure leads to as good as or better performance of VQ compared to other methods in the field of LSF coding. The use of this distance as the weighting function of the LSF transformed parameters is also suggested.