In this paper, we propose a method to reconstruct current distributions in the human brain from neuromagnetic measurements. The proposed method is based on the weighted lead-field synthetic (WLFS) filtering technique with the weighting factors calculated from the results of previous source space scanning. In this method, in addition to the depth normalization technique, weighting factors of the WLFS are determined by the cost values previously calculated based on the multiple signal classification (MUSIC) scan. We performed computer simulations of this method under noisy measurement conditions and compared the results to those obtained with the conventional WLFS method. The results of the simulations indicate that the proposed method is effective for the reconstruction of the current distributions in the human brain using magnetoencephalographic (MEG) measurements, even if the signal-to-noise ratio of the measured data is relatively low. We applied the proposed method to the magnetoencephalographic data obtained during a mental image processing task that included object recognition and mental rotation operations. The results suggest that the proposed method can extract the neural activity in the extrastriate visual region and the parietal region. These results are in agreement with the results of previous positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) studies.