In this paper, a new description of a separable-denominator (S-D) two-dimensional (2-D) transfer matrix is proposed, and its realization is considered. Some of this problem had been considered for the transfer matrices whose elements are two-variables rational functions. We shall propose a 2-D transfer matrix whose inputs-outputs relation is represented by a ratio of two-variables polynomial matrices, and present an algorithm to obtain a 2-D state-space model from it. Next, it is shown that the description proposed in this paper is always minimally realizable. And, we shall present a method of obtaining the description proposed in this paper from a S-D 2-D rational transfer matrix.