This paper describes how to generate, analyze and design a novel current-mode filter model using tunable multiple-output operational transconductance amplifiers and grounded capacitors (MO-OTA-Cs) for synthesizing both transmission poles and zeros. Transfer functions of low-order, high-order, general type, and special type are realized based on the filter model. The theory focuses mainly on establishing a relationship between the cascaded MO-OTA-Cs and the multiple-loop feedback matrix, which makes the structural generation and design formulas. Adopting the theory allows us to systematically generate many interesting new configurations along with some known structures. All the filter architectures contain only grounded capacitors, which can absorb parasitic capacitances and require smaller chip areas than floating ones. The paper also presents numerical design examples and simulation results to confirm the theoretical analysis.