Melanin, which is responsible for the appearance of spots and freckles, is an important indicator in evaluating skin condition. To assess the efficacy of cosmetics, skin condition scoring is performed by analyzing the distribution and amount of melanin from microscopic images of the stratum corneum cells. However, the current practice of diagnosing skin condition using stratum corneum cells images relies heavily on visual evaluation by experts. The goal of this study is to develop a quantitative evaluation system for skin condition based on melanin within unstained stratum corneum cells images. The proposed system utilizes principal component regression to perform five-level scoring, which is then compared with visual evaluation scores to assess the system’s usefulness. Additionally, we evaluated the impact of indicators related to melanin obtained from images on the scores, and verified which indicators are effective for evaluation. In conclusion, we confirmed that scoring is possible with an accuracy of more than 60% on a combination of several indicators, which is comparable to the accuracy of visual assessment.