In this paper, a smart dressing system was implemented based on flexible pH sensors that can monitor the infection of a wounded area by tracking the pH value of the area. Motivated by the fabrication process widely used for semiconductors, the flexible pH sensor fabrication process was devised with a polyester (PET) film and a Si wafer, which deposits Au and Ag on a PET film. Because the electrodes are comprised of a working electrode and a reference electrode, the reference electrode was fabricated by synthesizing the Polyaniline (PANI) on Ag/AgCl, while the pH sensor has four channels to evenly measure the pH value in a wide area. The smart dressing system was constructed with four pH sensors, a single temperature sensor, a level shifter, a regulator, an analog-to-digital converter (ADC), and a monitoring PC. The measurement results show that our smart dressing system has a size of 5×5cm2 and can monitor the pH value range found in [3,9] with a sensitivity slope of 50mV/pH.