IEICE TRANSACTIONS on Fundamentals
Delay Time Determination for the Timed Petri Net Model of a Signaling Pathway Based on Its Structural Information
Summary :
This paper proposes a method to incorporate the concept of time for the inclusion of dynamics of signaling pathway in a Petri net model, i.e., to use timed Petri nets. Incorporation of delay times into a Petri net model makes it possible to conduct quantitative evaluation on a target signaling pathway. However, experimental data describing detailed reactions are not available in most cases. An algorithm given in this paper determines delay times of a timed Petri net only from the structural information of it. The suitability of this algorithm has been confirmed by the results of an application to the IL-1 signaling pathway.
- Publication
- IEICE TRANSACTIONS on Fundamentals Vol.E93-A No.12 pp.2717-2729
- Publication Date
- 2010/12/01
- Publicized
- Online ISSN
- 1745-1337
- DOI
- 10.1587/transfun.E93.A.2717
- Type of Manuscript
- Special Section PAPER (Special Section on Theory of Concurrent Systems and its Applications)
- Category
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Yoshimasa MIWA, Yuki MURAKAMI, Qi-Wei GE, Chen LI, Hiroshi MATSUNO, Satoru MIYANO, "Delay Time Determination for the Timed Petri Net Model of a Signaling Pathway Based on Its Structural Information" in IEICE TRANSACTIONS on Fundamentals,
vol. E93-A, no. 12, pp. 2717-2729, December 2010, doi: 10.1587/transfun.E93.A.2717.
Abstract: This paper proposes a method to incorporate the concept of time for the inclusion of dynamics of signaling pathway in a Petri net model, i.e., to use timed Petri nets. Incorporation of delay times into a Petri net model makes it possible to conduct quantitative evaluation on a target signaling pathway. However, experimental data describing detailed reactions are not available in most cases. An algorithm given in this paper determines delay times of a timed Petri net only from the structural information of it. The suitability of this algorithm has been confirmed by the results of an application to the IL-1 signaling pathway.
URL: https://global.ieice.org/en_transactions/fundamentals/10.1587/transfun.E93.A.2717/_p
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@ARTICLE{e93-a_12_2717,
author={Yoshimasa MIWA, Yuki MURAKAMI, Qi-Wei GE, Chen LI, Hiroshi MATSUNO, Satoru MIYANO, },
journal={IEICE TRANSACTIONS on Fundamentals},
title={Delay Time Determination for the Timed Petri Net Model of a Signaling Pathway Based on Its Structural Information},
year={2010},
volume={E93-A},
number={12},
pages={2717-2729},
abstract={This paper proposes a method to incorporate the concept of time for the inclusion of dynamics of signaling pathway in a Petri net model, i.e., to use timed Petri nets. Incorporation of delay times into a Petri net model makes it possible to conduct quantitative evaluation on a target signaling pathway. However, experimental data describing detailed reactions are not available in most cases. An algorithm given in this paper determines delay times of a timed Petri net only from the structural information of it. The suitability of this algorithm has been confirmed by the results of an application to the IL-1 signaling pathway.},
keywords={},
doi={10.1587/transfun.E93.A.2717},
ISSN={1745-1337},
month={December},}
Copy
TY - JOUR
TI - Delay Time Determination for the Timed Petri Net Model of a Signaling Pathway Based on Its Structural Information
T2 - IEICE TRANSACTIONS on Fundamentals
SP - 2717
EP - 2729
AU - Yoshimasa MIWA
AU - Yuki MURAKAMI
AU - Qi-Wei GE
AU - Chen LI
AU - Hiroshi MATSUNO
AU - Satoru MIYANO
PY - 2010
DO - 10.1587/transfun.E93.A.2717
JO - IEICE TRANSACTIONS on Fundamentals
SN - 1745-1337
VL - E93-A
IS - 12
JA - IEICE TRANSACTIONS on Fundamentals
Y1 - December 2010
AB - This paper proposes a method to incorporate the concept of time for the inclusion of dynamics of signaling pathway in a Petri net model, i.e., to use timed Petri nets. Incorporation of delay times into a Petri net model makes it possible to conduct quantitative evaluation on a target signaling pathway. However, experimental data describing detailed reactions are not available in most cases. An algorithm given in this paper determines delay times of a timed Petri net only from the structural information of it. The suitability of this algorithm has been confirmed by the results of an application to the IL-1 signaling pathway.
ER -
English
