Delay Time Determination for the Timed Petri Net Model of a Signaling Pathway Based on Its Structural Information
Summary :
This paper proposes a method to incorporate the concept of time for the inclusion of dynamics of signaling pathway in a Petri net model, i.e., to use timed Petri nets. Incorporation of delay times into a Petri net model makes it possible to conduct quantitative evaluation on a target signaling pathway. However, experimental data describing detailed reactions are not available in most cases. An algorithm given in this paper determines delay times of a timed Petri net only from the structural information of it. The suitability of this algorithm has been confirmed by the results of an application to the IL-1 signaling pathway.
- Publication
- IEICE TRANSACTIONS on Fundamentals Vol.E93-A No.12 pp.2717-2729
- Publication Date
- 2010/12/01
- Publicized
- Online ISSN
- 1745-1337
- DOI
- 10.1587/transfun.E93.A.2717
- Type of Manuscript
- Special Section PAPER (Special Section on Theory of Concurrent Systems and its Applications)
- Category
Authors
Keyword
Latest Issue
Copyrights notice of machine-translated contents
The copyright of the original papers published on this site belongs to IEICE. Unauthorized use of the original or translated papers is prohibited. See IEICE Provisions on Copyright for details.
Cite this
Copy
Yoshimasa MIWA, Yuki MURAKAMI, Qi-Wei GE, Chen LI, Hiroshi MATSUNO, Satoru MIYANO, "Delay Time Determination for the Timed Petri Net Model of a Signaling Pathway Based on Its Structural Information" in IEICE TRANSACTIONS on Fundamentals,
vol. E93-A, no. 12, pp. 2717-2729, December 2010, doi: 10.1587/transfun.E93.A.2717.
Abstract: This paper proposes a method to incorporate the concept of time for the inclusion of dynamics of signaling pathway in a Petri net model, i.e., to use timed Petri nets. Incorporation of delay times into a Petri net model makes it possible to conduct quantitative evaluation on a target signaling pathway. However, experimental data describing detailed reactions are not available in most cases. An algorithm given in this paper determines delay times of a timed Petri net only from the structural information of it. The suitability of this algorithm has been confirmed by the results of an application to the IL-1 signaling pathway.
URL: https://global.ieice.org/en_transactions/fundamentals/10.1587/transfun.E93.A.2717/_p
Copy
@ARTICLE{e93-a_12_2717,
author={Yoshimasa MIWA, Yuki MURAKAMI, Qi-Wei GE, Chen LI, Hiroshi MATSUNO, Satoru MIYANO, },
journal={IEICE TRANSACTIONS on Fundamentals},
title={Delay Time Determination for the Timed Petri Net Model of a Signaling Pathway Based on Its Structural Information},
year={2010},
volume={E93-A},
number={12},
pages={2717-2729},
abstract={This paper proposes a method to incorporate the concept of time for the inclusion of dynamics of signaling pathway in a Petri net model, i.e., to use timed Petri nets. Incorporation of delay times into a Petri net model makes it possible to conduct quantitative evaluation on a target signaling pathway. However, experimental data describing detailed reactions are not available in most cases. An algorithm given in this paper determines delay times of a timed Petri net only from the structural information of it. The suitability of this algorithm has been confirmed by the results of an application to the IL-1 signaling pathway.},
keywords={},
doi={10.1587/transfun.E93.A.2717},
ISSN={1745-1337},
month={December},}
Copy
TY - JOUR
TI - Delay Time Determination for the Timed Petri Net Model of a Signaling Pathway Based on Its Structural Information
T2 - IEICE TRANSACTIONS on Fundamentals
SP - 2717
EP - 2729
AU - Yoshimasa MIWA
AU - Yuki MURAKAMI
AU - Qi-Wei GE
AU - Chen LI
AU - Hiroshi MATSUNO
AU - Satoru MIYANO
PY - 2010
DO - 10.1587/transfun.E93.A.2717
JO - IEICE TRANSACTIONS on Fundamentals
SN - 1745-1337
VL - E93-A
IS - 12
JA - IEICE TRANSACTIONS on Fundamentals
Y1 - December 2010
AB - This paper proposes a method to incorporate the concept of time for the inclusion of dynamics of signaling pathway in a Petri net model, i.e., to use timed Petri nets. Incorporation of delay times into a Petri net model makes it possible to conduct quantitative evaluation on a target signaling pathway. However, experimental data describing detailed reactions are not available in most cases. An algorithm given in this paper determines delay times of a timed Petri net only from the structural information of it. The suitability of this algorithm has been confirmed by the results of an application to the IL-1 signaling pathway.
ER -
English
