A Model for Ocular Dominance Plasticity Controlled by Feedforward and Feedback Inhibition
Summary :
The maturation of inhibitory transmission through γ-aminobutyric acid (GABA) is required to induce ocular dominance (OD) plasticity in the visual cortex. However, only circuits that are mediated by specific GABAA receptors can selectively elicit OD plasticity, implying a role of local circuits involved in GABA inhibition in this process. In this study, in order to theoretically examine the effects of such local pathways associated with cortical inhibition on the induction of OD plasticity, we compared synaptic modification dynamics regulated by feedforward inhibition and those regulated by feedback inhibition. Feedforward inhibition facilitated competitive interactions between different groups of inputs conveying correlated activities, which were required for the emergence of experience-dependent plasticity. Conversely, feedback inhibition suppressed competitive interactions and prevented synapses from reflecting past sensory experience. Our results suggest that the balance between feedforward and feedback inhibition regulates the timing and level of cortical plasticity by modulating competition among synapses. This result suggests an importance of activity-dependent competition in experience-dependent OD plasticity, which is in line with the results of previous experiments.
- Publication
- IEICE TRANSACTIONS on Fundamentals Vol.E97-A No.8 pp.1780-1786
- Publication Date
- 2014/08/01
- Publicized
- Online ISSN
- 1745-1337
- DOI
- 10.1587/transfun.E97.A.1780
- Type of Manuscript
- PAPER
- Category
- General Fundamentals and Boundaries
Authors
Ichiro SAKURAI
Tohoku University
Shigeru KUBOTA
Yamagata University
Michio NIWANO
Tohoku University
Keyword
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Ichiro SAKURAI, Shigeru KUBOTA, Michio NIWANO, "A Model for Ocular Dominance Plasticity Controlled by Feedforward and Feedback Inhibition" in IEICE TRANSACTIONS on Fundamentals,
vol. E97-A, no. 8, pp. 1780-1786, August 2014, doi: 10.1587/transfun.E97.A.1780.
Abstract: The maturation of inhibitory transmission through γ-aminobutyric acid (GABA) is required to induce ocular dominance (OD) plasticity in the visual cortex. However, only circuits that are mediated by specific GABAA receptors can selectively elicit OD plasticity, implying a role of local circuits involved in GABA inhibition in this process. In this study, in order to theoretically examine the effects of such local pathways associated with cortical inhibition on the induction of OD plasticity, we compared synaptic modification dynamics regulated by feedforward inhibition and those regulated by feedback inhibition. Feedforward inhibition facilitated competitive interactions between different groups of inputs conveying correlated activities, which were required for the emergence of experience-dependent plasticity. Conversely, feedback inhibition suppressed competitive interactions and prevented synapses from reflecting past sensory experience. Our results suggest that the balance between feedforward and feedback inhibition regulates the timing and level of cortical plasticity by modulating competition among synapses. This result suggests an importance of activity-dependent competition in experience-dependent OD plasticity, which is in line with the results of previous experiments.
URL: https://global.ieice.org/en_transactions/fundamentals/10.1587/transfun.E97.A.1780/_p
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@ARTICLE{e97-a_8_1780,
author={Ichiro SAKURAI, Shigeru KUBOTA, Michio NIWANO, },
journal={IEICE TRANSACTIONS on Fundamentals},
title={A Model for Ocular Dominance Plasticity Controlled by Feedforward and Feedback Inhibition},
year={2014},
volume={E97-A},
number={8},
pages={1780-1786},
abstract={The maturation of inhibitory transmission through γ-aminobutyric acid (GABA) is required to induce ocular dominance (OD) plasticity in the visual cortex. However, only circuits that are mediated by specific GABAA receptors can selectively elicit OD plasticity, implying a role of local circuits involved in GABA inhibition in this process. In this study, in order to theoretically examine the effects of such local pathways associated with cortical inhibition on the induction of OD plasticity, we compared synaptic modification dynamics regulated by feedforward inhibition and those regulated by feedback inhibition. Feedforward inhibition facilitated competitive interactions between different groups of inputs conveying correlated activities, which were required for the emergence of experience-dependent plasticity. Conversely, feedback inhibition suppressed competitive interactions and prevented synapses from reflecting past sensory experience. Our results suggest that the balance between feedforward and feedback inhibition regulates the timing and level of cortical plasticity by modulating competition among synapses. This result suggests an importance of activity-dependent competition in experience-dependent OD plasticity, which is in line with the results of previous experiments.},
keywords={},
doi={10.1587/transfun.E97.A.1780},
ISSN={1745-1337},
month={August},}
Copy
TY - JOUR
TI - A Model for Ocular Dominance Plasticity Controlled by Feedforward and Feedback Inhibition
T2 - IEICE TRANSACTIONS on Fundamentals
SP - 1780
EP - 1786
AU - Ichiro SAKURAI
AU - Shigeru KUBOTA
AU - Michio NIWANO
PY - 2014
DO - 10.1587/transfun.E97.A.1780
JO - IEICE TRANSACTIONS on Fundamentals
SN - 1745-1337
VL - E97-A
IS - 8
JA - IEICE TRANSACTIONS on Fundamentals
Y1 - August 2014
AB - The maturation of inhibitory transmission through γ-aminobutyric acid (GABA) is required to induce ocular dominance (OD) plasticity in the visual cortex. However, only circuits that are mediated by specific GABAA receptors can selectively elicit OD plasticity, implying a role of local circuits involved in GABA inhibition in this process. In this study, in order to theoretically examine the effects of such local pathways associated with cortical inhibition on the induction of OD plasticity, we compared synaptic modification dynamics regulated by feedforward inhibition and those regulated by feedback inhibition. Feedforward inhibition facilitated competitive interactions between different groups of inputs conveying correlated activities, which were required for the emergence of experience-dependent plasticity. Conversely, feedback inhibition suppressed competitive interactions and prevented synapses from reflecting past sensory experience. Our results suggest that the balance between feedforward and feedback inhibition regulates the timing and level of cortical plasticity by modulating competition among synapses. This result suggests an importance of activity-dependent competition in experience-dependent OD plasticity, which is in line with the results of previous experiments.
ER -
English
