IEICE TRANSACTIONS on Information
MicroRNA Expression Profiles for Classification and Analysis of Tumor Samples
Summary :
One kind of functional noncoding RNAs, microRNAs (miRNAs), form a class of endogenous RNAs that can have important regulatory roles in animals and plants by targeting transcripts for cleavage or translation repression. Researches on both experimental and computational approaches have shown that miRNAs indeed involve in the human cancer development and progression. However, the miRNAs that contribute more information to the distinction between the normal and tumor samples (tissues) are still undetermined. Recently, the high-throughput microarray technology was used as a powerful technique to measure the expression level of miRNAs in cells. Analyzing this expression data can allow us to determine the functional roles of miRNAs in the living cells. In this paper, we present a computational method to (1) predicting the tumor tissues using high-throughput miRNA expression profiles; (2) finding the informative miRNAs that show strong distinction of expression level in tumor tissues. To this end, we perform a support vector machine (SVM) based method to deeply examine one recent miRNA expression dataset. The experimental results show that SVM-based method outperforms other supervised learning methods such as decision trees, Bayesian networks, and backpropagation neural networks. Furthermore, by using the miRNA-target information and Gene Ontology annotations, we showed that the informative miRNAs have strong evidences related to some types of human cancer including breast, lung, and colon cancer.
- Publication
- IEICE TRANSACTIONS on Information Vol.E94-D No.3 pp.416-422
- Publication Date
- 2011/03/01
- Publicized
- Online ISSN
- 1745-1361
- DOI
- 10.1587/transinf.E94.D.416
- Type of Manuscript
- Special Section PAPER (Special Section on Knowledge Discovery, Data Mining and Creativity Support System)
- Category
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Dang Hung TRAN, Tu Bao HO, Tho Hoan PHAM, Kenji SATOU, "MicroRNA Expression Profiles for Classification and Analysis of Tumor Samples" in IEICE TRANSACTIONS on Information,
vol. E94-D, no. 3, pp. 416-422, March 2011, doi: 10.1587/transinf.E94.D.416.
Abstract: One kind of functional noncoding RNAs, microRNAs (miRNAs), form a class of endogenous RNAs that can have important regulatory roles in animals and plants by targeting transcripts for cleavage or translation repression. Researches on both experimental and computational approaches have shown that miRNAs indeed involve in the human cancer development and progression. However, the miRNAs that contribute more information to the distinction between the normal and tumor samples (tissues) are still undetermined. Recently, the high-throughput microarray technology was used as a powerful technique to measure the expression level of miRNAs in cells. Analyzing this expression data can allow us to determine the functional roles of miRNAs in the living cells. In this paper, we present a computational method to (1) predicting the tumor tissues using high-throughput miRNA expression profiles; (2) finding the informative miRNAs that show strong distinction of expression level in tumor tissues. To this end, we perform a support vector machine (SVM) based method to deeply examine one recent miRNA expression dataset. The experimental results show that SVM-based method outperforms other supervised learning methods such as decision trees, Bayesian networks, and backpropagation neural networks. Furthermore, by using the miRNA-target information and Gene Ontology annotations, we showed that the informative miRNAs have strong evidences related to some types of human cancer including breast, lung, and colon cancer.
URL: https://global.ieice.org/en_transactions/information/10.1587/transinf.E94.D.416/_p
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@ARTICLE{e94-d_3_416,
author={Dang Hung TRAN, Tu Bao HO, Tho Hoan PHAM, Kenji SATOU, },
journal={IEICE TRANSACTIONS on Information},
title={MicroRNA Expression Profiles for Classification and Analysis of Tumor Samples},
year={2011},
volume={E94-D},
number={3},
pages={416-422},
abstract={One kind of functional noncoding RNAs, microRNAs (miRNAs), form a class of endogenous RNAs that can have important regulatory roles in animals and plants by targeting transcripts for cleavage or translation repression. Researches on both experimental and computational approaches have shown that miRNAs indeed involve in the human cancer development and progression. However, the miRNAs that contribute more information to the distinction between the normal and tumor samples (tissues) are still undetermined. Recently, the high-throughput microarray technology was used as a powerful technique to measure the expression level of miRNAs in cells. Analyzing this expression data can allow us to determine the functional roles of miRNAs in the living cells. In this paper, we present a computational method to (1) predicting the tumor tissues using high-throughput miRNA expression profiles; (2) finding the informative miRNAs that show strong distinction of expression level in tumor tissues. To this end, we perform a support vector machine (SVM) based method to deeply examine one recent miRNA expression dataset. The experimental results show that SVM-based method outperforms other supervised learning methods such as decision trees, Bayesian networks, and backpropagation neural networks. Furthermore, by using the miRNA-target information and Gene Ontology annotations, we showed that the informative miRNAs have strong evidences related to some types of human cancer including breast, lung, and colon cancer.},
keywords={},
doi={10.1587/transinf.E94.D.416},
ISSN={1745-1361},
month={March},}
Copy
TY - JOUR
TI - MicroRNA Expression Profiles for Classification and Analysis of Tumor Samples
T2 - IEICE TRANSACTIONS on Information
SP - 416
EP - 422
AU - Dang Hung TRAN
AU - Tu Bao HO
AU - Tho Hoan PHAM
AU - Kenji SATOU
PY - 2011
DO - 10.1587/transinf.E94.D.416
JO - IEICE TRANSACTIONS on Information
SN - 1745-1361
VL - E94-D
IS - 3
JA - IEICE TRANSACTIONS on Information
Y1 - March 2011
AB - One kind of functional noncoding RNAs, microRNAs (miRNAs), form a class of endogenous RNAs that can have important regulatory roles in animals and plants by targeting transcripts for cleavage or translation repression. Researches on both experimental and computational approaches have shown that miRNAs indeed involve in the human cancer development and progression. However, the miRNAs that contribute more information to the distinction between the normal and tumor samples (tissues) are still undetermined. Recently, the high-throughput microarray technology was used as a powerful technique to measure the expression level of miRNAs in cells. Analyzing this expression data can allow us to determine the functional roles of miRNAs in the living cells. In this paper, we present a computational method to (1) predicting the tumor tissues using high-throughput miRNA expression profiles; (2) finding the informative miRNAs that show strong distinction of expression level in tumor tissues. To this end, we perform a support vector machine (SVM) based method to deeply examine one recent miRNA expression dataset. The experimental results show that SVM-based method outperforms other supervised learning methods such as decision trees, Bayesian networks, and backpropagation neural networks. Furthermore, by using the miRNA-target information and Gene Ontology annotations, we showed that the informative miRNAs have strong evidences related to some types of human cancer including breast, lung, and colon cancer.
ER -
English
