To simultaneously enhance data rate and physical layer security (PLS) for low-luminance smartphone screen to camera uplink communication, space division multiplexing using high-luminance cell-size reduction arrangement is numerically analyzed and experimentally verified. The uplink consists of a low-luminance smartphone screen and an indoor telephoto camera at a long distance of 3.5 meters. The high-luminance cell-size reduction arrangement avoids the influence of spatial inter-symbol interference (ISI) and ambient light to obtain a stable low-luminance screen. To reduce the screen luminance without decreasing the screen pixel value, the arrangement reduces only the high-luminance cell area while keeping the cell spacing. In this study, two technical issues related to high-luminance cell-size reduction arrangement are solved. First, a numerical analysis and experimental results show that the high-luminance cell-size reduction arrangement is more effective in reducing the spatial ISI at low luminance than the conventional low-luminance cell arrangement. Second, in view point of PLS enhancement at wide angles, symbol error rate should be low in front of the screen and high at wide angles. A numerical analysis and experimental results show that the high-luminance cell-size reduction arrangement is more suitable for enhancing PLS at wide angles than the conventional low-luminance cell arrangement.