Emergency Medical Services (EMS) play a crucial role in healthcare systems, managing pre-hospital or out-of-hospital emergencies from the onset of an emergency call to the patient’s arrival at a healthcare facility. The design of an efficient ambulance location model is pivotal in enhancing survival rates, controlling morbidity, and preventing disability. Key factors in the classical models typically include travel time, demand zones, and the number of stations. While urban EMS systems have received extensive examination due to their centralized populations, rural areas pose distinct challenges. These include lower population density and longer response distances, contributing to a higher fatality rate due to sparse population distribution, limited EMS stations, and extended travel times. To address these challenges, we introduce a novel mathematical model that aims to optimize coverage and equity. A distinctive feature of our model is the integration of equity within the objective function, coupled with a focus on practical response time that includes the period required for personal protective equipment procedures, ensuring the model’s applicability and realism in emergency response scenarios. We tackle the proposed problem using a tailored genetic algorithm and propose a greedy algorithm for solution construction. The implementation of our tailored Genetic Algorithm promises efficient and effective EMS solutions, potentially enhancing emergency care and health outcomes in rural communities.