To measure the detrusor pressure for diagnosing lower urinary tract symptoms, we designed a small-area and low-power System on a Chip (SoC). The SoC should be small and low power because it is encapsulated in tiny air-tight capsules which are simultaneously inserted in the urinary bladder and rectum for several days. Since the SoC is also required to be programmable, we designed an Application Specific Instruction set Processor (ASIP) for pressure measurement and wireless communication, and implemented almost required functions on the ASIP. The SoC was fabricated using a 0.18 µm CMOS mixed-signal process and the chip size is 2.5 2.5 mm2. Evaluation results show that the power consumption of the SoC is 93.5 µW, and that it can operate the capsule for seven days with a tiny battery.