This paper proposes an area- and energy-efficient DLL-based body bias generator (BBG) for minimum energy operation that controls p-well and n-well bias independently. The BBG can minimize total energy consumption of target circuits under a skewed process condition between nMOSFETs and pMOSFETs. The proposed BBG is composed of digital cells compatible with cell-based design, which enables energy- and area-efficient implementation without additional supply voltages. A test circuit is implemented in a 65-nm FDSOI process. Measurement results using a 32-bit RISC processor on the same chip show that the proposed BBG can reduce energy consumption close to a minimum within a 3% energy loss. In this condition, energy and area overheads of the BBG are 0.2% and 0.12%, respectively.