PID control schemes based on the classical control theory, have been widely used for various real control systems. However, in practice, since it is considerably difficult to determine the PID parameters suitably, lots of researches have been reported with respect to tuning schemes of PID parameters. Furthermore, several self-tuning and auto-tuning techniques in the PID control have been reported for systems with unknown or slowly time-varying parameters. On the other hand, so-called a generalized predictive control (GPC) scheme has been reported as a useful self-tuning control technique for unknown and/or time variant delay systems. In this paper, a new self-tuning predictive PID control algorithm based on a GPC criterion is proposed.