The brain-machine interface (BMI) is a new method for man-machine interface, which enables us to control machines and to communicate with others, without input devices but directly using brain signals. Previously, we successfully developed a real time control system for operating a robot arm using brain-machine interfaces based on the brain surface electrodes, with the purpose of restoring motor and communication functions in severely disabled people such as amyotrophic lateral sclerosis patients. A fully-implantable wireless system is indispensable for the clinical application of invasive BMI in order to reduce the risk of infection. This system includes many new technologies such as two 64-channel integrated analog amplifier chips, a Bluetooth wireless data transfer circuit, a wirelessly rechargeable battery, 3 dimensional tissue-fitting high density electrodes, a titanium head casing, and a fluorine polymer body casing. This paper describes key features of the first prototype of the BMI system for clinical application.

Magnetoencephalography (MEG) measures very weak neuromagnetic signals using SQUID sensors. Standard MEG analyses include averaged waveforms, isofield maps and equivalent current dipoles. Beamforming MEG analyses provide us with frequency-dependent spatiotemporal information about the cerebral oscillatory changes related to not only somatosensory processing but also language processing. Language dominance is able to be evaluated using laterality of power attenuation in the low γ band in the frontal area. Neuromagnetic signals of the unilateral upper movements are able to be decoded using a support vector machine.