Mobility Robustness Optimization (MRO) is one of the most important goals in LTE-Advanced Self-Organizing Networks (SON). Seamless handover in femtocell network is urgent and challenging, which has not been paid enough attention. Handover decision parameters, such as Time-To-Trigger (TTT), Hysteresis, Cell Individual Offset (CIO), have great effect on mobility performance, which may lead to Radio Link Failures (RLFs) and Unnecessary Handover. This letter proposes a handover parameters optimization approach based on Ant Colony Algorithm in the femtocell networks. The simulation result shows that the proposed scheme has a better performance than the fixed parameters method.