Low-profile inverter power supplies are increasingly required for backlight systems of liquid crystal displays (LCDs). A great deal of attention has been focused on the application of piezoelectric transformers (PTs) to such power supplies. To miniaturize PT inverters still further, PTs need to have sufficient high voltage-step-up-ratio, which can be achieved by a multilayered PT. First, this paper describes a method for simulating such performance using a distributed constant equivalent circuit model. The results of the simulation for a multilayered PT operated in the third order longitudinal vibration mode show that the resistance of internal electrodes causes the dominant loss factor. Next, a power inverter incorporating the multilayered PT was fabricated. This power inverter can be operated over a wide input DC voltage range from 7-20 V. Regarding a conventional inverter drive circuit, when input DC voltage range was extended, the inverter efficiency remarkably decreased. For the reason, we developed a new inverter circuit, which is equipped with an automatic drive voltage control circuit to maintain the drive voltage to the PT at a constant value. As a result, the fabricated power inverter exhibited more than 90% overall efficiency and 3.5 W output power, which is enough to light up a 12.1-inch color LCD. The maximum luminance efficiency on a light transmission plate of the backlight was as high as 30 cd/m2/W.